Introducing Natura-1, our first general foundation model for the physical world. It follows natural-language instructions zero-shot and turns them into action with dexterous hands. Natura-1 is a 50-billion-parameter mixture-of-experts (MoE) model pretrained on one million hours of egocentric human experience. On top of this foundation, we conduct efficient post-training on a limited amount of robot data to adapt pretrained world knowledge to dexterous manipulation, yielding a model that generalizes to a wide range of unseen scenarios. Natura-1 follows complex natural-language instructions zero-shot, reasoning through spatial constraints, multi-object relationships, and negative conditions. It can also autonomously carry out long and continuous workflows to perform long-horizon executions. Natura-1 provides early evidence that generalization—and even emergent behavior—can coexist with the complexity of dexterous hands. Further progress depends on the full stack: infrastructure for faster training and real-time inference, pretraining data at greater scale and coverage, and models that transfer to robots with less adaptation. We expect it to be a long-term research and engineering effort.